ZNF593
Chr 1zinc finger protein 593
Also known as: ZT86
This zinc finger protein promotes nuclear export of the 60S ribosomal subunit during ribosome maturation and negatively regulates Oct-2 transcription factor activity. The gene shows low constraint against loss-of-function variants (pLI = 0.0007, LOEUF = 1.69), suggesting loss-of-function variants are generally well-tolerated in the population. No established disease associations have been reported for ZNF593 mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF593 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools