ZNF362
Chr 1zinc finger protein 362
Also known as: LIN29, RN, lin-29
The ZNF362 protein is a DNA-binding transcription factor that regulates gene transcription by RNA polymerase II in the nucleus. This gene is highly constrained against loss-of-function variants (pLI 0.94, LOEUF 0.35), suggesting that mutations would likely cause significant developmental or neurological phenotypes, though specific disease associations have not yet been established in humans.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF362 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools