ZNF32

Chr 10

zinc finger protein 32

Also known as: KOX30, ZNF637, Zfp637

NCBI Gene: 7580ENSG00000169740UniProt: P17041OMIM: 194539

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.90
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.90LOEUF
pLI 0.033
Z-score 1.80
OE 0.39 (0.19–0.90)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.42Z-score
OE missense 0.67 (0.57–0.79)
99 obs / 147.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.39 (0.19–0.90)
0≤0.351.4
Missense OE?0.67 (0.57–0.79)
0≤0.61.4
Synonymous OE?0.87
0≤1.21.6
LoF obs/exp: 4 / 10.2Missense obs/exp: 99 / 147.6Syn Z: 0.78

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZNF32 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients