ZNF319

Chr 16

zinc finger protein 319

Also known as: ZFP319

NCBI Gene: 57567 ENSG00000166188 UniProt: Q9P2F9

This protein is predicted to regulate transcription by RNA polymerase II through DNA binding and zinc ion binding activities in the nucleus. The gene is highly constrained against loss-of-function variants (pLI 0.99, LOEUF 0.25), but no specific disease associations have been established in the provided data. Inheritance pattern cannot be determined from the available information.

ResearchSummary from RefSeq, UniProt

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.25

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429