ZNF319

Chr 16

zinc finger protein 319

Also known as: ZFP319

NCBI Gene: 57567 ENSG00000166188 UniProt: Q9P2F9

This protein is predicted to regulate transcription by RNA polymerase II through DNA binding and zinc ion binding activities in the nucleus. The gene is highly constrained against loss-of-function variants (pLI 0.99, LOEUF 0.25), but no specific disease associations have been established in the provided data. Inheritance pattern cannot be determined from the available information.

ResearchSummary from RefSeq, UniProt

Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

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Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

LOF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in ZNF319?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 150

674 rare PASS variants

Rare truncating (LoF)

1 in 12,000

40 rare PASS variants

Rare synonymous (reference)

1 in 110

397 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for ZNF319. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 160	1 in 18,000
South Asian	~43k	1 in 120	1 in 7,100
Remaining (unassigned)	~30k	1 in 150	1 in 6,000
European (Finnish)	~27k	1 in 200	1 in 3,200
Admixed American	~22k	1 in 83	none seen
African / African American	~21k	1 in 120	≈ 1 in 21,000
East Asian	~20k	1 in 130	none seen
Ashkenazi Jewish	~13k	1 in 520	none seen
Middle Eastern	~2,884	1 in 120	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 1 coding exons well covered in gnomAD exomes and genomes.? see exons ↓