ZNF286A-TBC1D26

Chr 17

ZNF286A-TBC1D26 readthrough (NMD candidate)

NCBI Gene: 119086082ENSG00000255104

This locus represents naturally occurring read-through transcription between the neighboring ZNF286A and TBC1D26 genes. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2020]

121
ClinVar variants
10
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— ZNF286A-TBC1D26
📋
ClinVar Variants
10 Pathogenic / Likely Pathogenic· 98 VUS of 121 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

121 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic10
VUS98
Likely Benign11
Benign2
10
Pathogenic
98
VUS
11
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
10
0
10
Likely Pathogenic
0
0
0
0
0
VUS
1
96
1
0
98
Likely Benign
0
9
0
2
11
Benign
0
0
2
0
2
Total1105132121

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

ZNF286A-TBC1D26 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for ZNF286A-TBC1D26

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools