ZNF277
Chr 7zinc finger protein 277
Also known as: NRIF4, ZNF277P
The protein is a transcription factor that represses transcription of the tumor suppressor gene INK4A/ARF and modulates cellular senescence, possibly through interaction with the Polycomb group complex PRC1. Based on the extremely low pLI score and high LOEUF value, this gene appears highly tolerant to loss-of-function mutations, suggesting pathogenic variants are unlikely to cause disease through haploinsufficiency. No established neurogenetic disorders have been associated with ZNF277 mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
108 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 19 | 0 | 19 |
Likely Pathogenic | 0 | 0 | 2 | 0 | 2 |
VUS | 1 | 43 | 17 | 0 | 61 |
Likely Benign | 0 | 2 | 4 | 3 | 9 |
Benign | 1 | 0 | 0 | 0 | 1 |
Conflicting | — | 1 | |||
| Total | 2 | 45 | 42 | 3 | 93 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ZNF277 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools