ZNF276
Chr 16zinc finger protein 276
Also known as: CENP-Z, CENPZ, ZADT, ZFP276, ZNF477
ZNF276 encodes a transcription factor that binds to specific DNA sequences and regulates gene expression by RNA polymerase II, with additional localization to the kinetochore during cell division. Mutations cause autosomal recessive neurodevelopmental disorder with seizures, microcephaly, and developmental delay. The gene is highly constrained against loss-of-function variants in the general population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF276 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools