ZNF276

Chr 16

zinc finger protein 276

Also known as: CENP-Z, CENPZ, ZADT, ZFP276, ZNF477

NCBI Gene: 92822ENSG00000158805UniProt: Q8N554

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.75
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.75LOEUF
pLI 0.000
Z-score 2.56
OE 0.47 (0.31–0.75)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-1.77Z-score
OE missense 1.27 (1.17–1.37)
439 obs / 346.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.47 (0.31–0.75)
0≤0.351.4
Missense OE?1.27 (1.17–1.37)
0≤0.61.4
Synonymous OE?1.48
0≤1.21.6
LoF obs/exp: 13 / 27.5Missense obs/exp: 439 / 346.5Syn Z: -4.62

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZNF276 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients