ZNF273

Chr 7

zinc finger protein 273

Also known as: HZF9

This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.34
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.34LOEUF
pLI 0.027
Z-score 1.05
OE 0.53 (0.241.34)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.38Z-score
OE missense 0.94 (0.851.04)
269 obs / 287.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.53 (0.241.34)
00.351.4
Missense OE?0.94 (0.851.04)
00.61.4
Synonymous OE?0.98
01.21.6
LoF obs/exp: 3 / 5.7Missense obs/exp: 269 / 287.3Syn Z: 0.14

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF273 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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