ZNF25

Chr 10

zinc finger protein 25

Also known as: KOX19, Zfp9

NCBI Gene: 219749ENSG00000175395UniProt: P17030

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.91
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.91LOEUF
pLI 0.000
Z-score 1.87
OE 0.53 (0.33–0.91)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.15Z-score
OE missense 1.03 (0.92–1.15)
237 obs / 230.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.53 (0.33–0.91)
0≤0.351.4
Missense OE?1.03 (0.92–1.15)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 10 / 18.7Missense obs/exp: 237 / 230.5Syn Z: 0.22

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZNF25 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients