ZNF142
Chr 2ARzinc finger protein 142
Also known as: HA4654, NEDISHM, pHZ-49
The protein is a transcriptional regulator containing 31 C2H2-type zinc fingers from the Kruppel family. Biallelic mutations cause a neurodevelopmental disorder with impaired speech and hyperkinetic movements, inherited in an autosomal recessive pattern. The gene shows relatively low constraint to loss-of-function variants.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF142 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools