ZNF141

Chr 4

zinc finger protein 141

Also known as: D4S90, pHZ-44

The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtPolydactyly, postaxial A6
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.25
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.25LOEUF
pLI 0.104
Z-score 1.23
OE 0.40 (0.161.25)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.22Z-score
OE missense 0.96 (0.861.07)
232 obs / 241.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.40 (0.161.25)
00.351.4
Missense OE?0.96 (0.861.07)
00.61.4
Synonymous OE?0.99
01.21.6
LoF obs/exp: 2 / 5.0Missense obs/exp: 232 / 241.8Syn Z: 0.05

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF141 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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