ZNF107

Chr 7

zinc finger protein 107

Also known as: Y8, ZFD25, ZNF588, smap-7

This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.90
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.90LOEUF
pLI 0.021
Z-score -0.20
OE 1.17 (0.401.90)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.52Z-score
OE missense 1.08 (0.991.17)
408 obs / 379.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.17 (0.401.90)
00.351.4
Missense OE?1.08 (0.991.17)
00.61.4
Synonymous OE?0.99
01.21.6
LoF obs/exp: 2 / 1.7Missense obs/exp: 408 / 379.3Syn Z: 0.12

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF107 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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