ZMYND15
Chr 17ARzinc finger MYND-type containing 15
Also known as: SPGF14
This protein acts as a transcriptional repressor by recruiting histone deacetylases to regulate gene expression during spermatogenesis. Mutations cause spermatogenic failure 14, which follows autosomal recessive inheritance. The gene shows very low constraint against loss-of-function variants (pLI near zero), consistent with a recessive disorder pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
193 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 5 | 0 | 20 | 0 | 25 |
Likely Pathogenic | 5 | 0 | 1 | 0 | 6 |
VUS | 0 | 110 | 13 | 0 | 123 |
Likely Benign | 1 | 9 | 2 | 5 | 17 |
Benign | 0 | 1 | 0 | 2 | 3 |
Conflicting | — | 1 | |||
| Total | 11 | 120 | 36 | 7 | 175 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ZMYND15 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools