ZG16

Chr 16

zymogen granule protein 16

Also known as: JCLN, JCLN1, ZG16A

NCBI Gene: 653808 ENSG00000174992 UniProt: O60844

ZG16 encodes a protein that functions in protein trafficking and may serve as a linker molecule during secretory granule formation in the trans-Golgi network, with predicted carbohydrate and peptidoglycan binding activities. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.647), but no established human genetic diseases have been definitively associated with ZG16 mutations based on the available data.

ResearchSummary from RefSeq, UniProt

Predicted to enable carbohydrate binding activity and peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in Golgi lumen and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.65

LOEUF

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Mechanism

Some data sources returned errors (1)

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