ZG16
Chr 16zymogen granule protein 16
Also known as: JCLN, JCLN1, ZG16A
ZG16 encodes a protein that functions in protein trafficking and may serve as a linker molecule during secretory granule formation in the trans-Golgi network, with predicted carbohydrate and peptidoglycan binding activities. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.647), but no established human genetic diseases have been definitively associated with ZG16 mutations based on the available data.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
199 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 150 |
Likely Pathogenic | — | — | — | — | 41 |
VUS | — | — | — | — | 5 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 3 |
| Total | — | 199 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ZG16 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools