ZFYVE26
Chr 14ARzinc finger FYVE-type containing 26
Also known as: FYVE-CENT, SPG15
The protein contains a FYVE zinc finger domain that targets it to membrane lipids through phospholipid interactions and localizes to the cytoplasm, cytoskeleton, and centrosome. Mutations cause autosomal recessive spastic paraplegia-15, a hereditary spastic paraplegia characterized by progressive lower limb spasticity and weakness. The pathogenic mechanism involves disruption of the protein's membrane targeting function and its role in centrosomal organization.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZFYVE26 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools