ZFTRAF1
Chr 8zinc finger TRAF-type and ring finger containing 1
Also known as: CHRP, CYHR1
Clinical highlights
Interpreting a novel variant
Loss of function is the curated mechanism (Gene2Phenotype) and the gene is intolerant of it in the population — truncating, frameshift and canonical splice variants carry more prior weight here than missense.Curated gene-level mechanism — a prior for triage, not a per-variant call.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Missense constrained — critical functional residues
LoF Constraint?
0.53LOEUF
pLI 0.491
Z-score 2.83
OE 0.20 (0.09–0.53)
More LoF-intolerant than ~75% of genes
Missense Constraint?
3.15Z-score
OE missense 0.42 (0.35–0.49)
96 obs / 230.9 exp
Highly missense-constrained (top ~0.1%)
Observed / Expected Ratios?
LoF OE?0.20 (0.09–0.53)
0≤0.351.4
Missense OE?0.42 (0.35–0.49)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 3 / 14.7Missense obs/exp: 96 / 230.9Syn Z: 0.29
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZFTRAF1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools