ZFP91-CNTF

Chr 11

ZFP91-CNTF readthrough (NMD candidate)

This gene represents a read-through transcript composed of ZFP91 and CNTF sequence. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Aug 2008]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in ZFP91-CNTF?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 110

624 rare PASS variants

Rare truncating (LoF)

1 in 5,300

38 rare PASS variants

Rare synonymous (reference)

1 in 190

330 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for ZFP91-CNTF. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 230	1 in 5,400
South Asian	~43k	1 in 120	≈ 1 in 9,600
Remaining (unassigned)	~30k	1 in 110	1 in 4,100
European (Finnish)	~27k	1 in 450	≈ 1 in 6,500
Admixed American	~22k	1 in 84	1 in 2,500
African / African American	~21k	1 in 57	≈ 1 in 8,000
East Asian	~20k	1 in 98	1 in 1,400
Ashkenazi Jewish	~13k	1 in 760	none seen
Middle Eastern	~2,884	1 in 73	≈ 1 in 2,900

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.