ZFP64

Chr 20

ZFP64 zinc finger protein

Also known as: ZNF338

NCBI Gene: 55734ENSG00000020256UniProt: Q9NTW7OMIM: 618111

Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in mesenchymal cell differentiation. Located in cytoplasm and megasporocyte nucleus. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
9
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.76
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.76LOEUF
pLI 0.000
Z-score 2.42
OE 0.45 (0.28–0.76)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.94Z-score
OE missense 0.74 (0.67–0.81)
315 obs / 428.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.45 (0.28–0.76)
0≤0.351.4
Missense OE?0.74 (0.67–0.81)
0≤0.61.4
Synonymous OE?1.01
0≤1.21.6
LoF obs/exp: 10 / 22.4Missense obs/exp: 315 / 428.0Syn Z: -0.12

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZFP64 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients