ZFAND2A

Chr 7

zinc finger AN1-type containing 2A

ENSG00000178381UniProt: Q8N6M9
0
ClinVar variants
0
Pathogenic / LP
0.00
pLI score
0
Active trials
Clinical Summary— ZFAND2A
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Some data sources returned errors (2)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.69LOEUF
pLI 0.003
Z-score 0.41
OE 0.80 (0.39–1.69)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
-0.95Z-score
OE missense 1.29 (1.10–1.51)
109 obs / 84.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.80 (0.39–1.69)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.1.29 (1.10–1.51)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.1.51
0≤1.21.6
LoF obs/exp: 4 / 5.0Missense obs/exp: 109 / 84.5Syn Z: -2.23

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZFAND2A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Single-Cell RNA-Seq Recognized Key Genes for Metastasis and Macrophage Infiltration in Colorectal Cancer.
Shi J et al.·Hum Mutat
2025
Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder.
Zillich E et al.·Transl Psychiatry
2024
COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration.
Lu ZY et al.·FASEB J
2025
Copper toxicity of inflection point in human intestinal cell line Caco-2 dissected: influence of temporal expression patterns.
Keenan J et al.·In Vitro Cell Dev Biol Anim
2021
Meta-Analysis of Heat-Stressed Transcriptomes Using the Public Gene Expression Database from Human and Mouse Samples.
Yonezawa S et al.·Int J Mol Sci
2023Meta-analysis
Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium.
Garrett SH et al.·BMC Med Genomics
2013
Copper activation of NF-kappaB signaling in HepG2 cells.
McElwee MK et al.·J Mol Biol
2009
Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networks.
Pronk TE et al.·J Appl Toxicol
2013Functional
Genomic discovery of EF-24 targets unveils antitumorigenic mechanisms in leukemia cells.
Singh AP et al.·PLoS One
2025Functional
The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2.
Pizzato Scomazzon S et al.·Mol Cancer Res
2019
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools