ZDHHC6

Chr 10

zDHHC palmitoyltransferase 6

Also known as: DHHC-6, DHHC6, ZNF376

NCBI Gene: 64429ENSG00000023041UniProt: Q9H6R6

Enables palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in intracellular signal transduction. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.78
LOEUF
GOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.78LOEUF
pLI 0.000
Z-score 2.40
OE 0.48 (0.31–0.78)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.71Z-score
OE missense 0.87 (0.77–0.98)
191 obs / 220.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.48 (0.31–0.78)
0≤0.351.4
Missense OE?0.87 (0.77–0.98)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 12 / 25.0Missense obs/exp: 191 / 220.6Syn Z: 1.29

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZDHHC6 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients