ZDHHC21

Chr 9

zDHHC palmitoyltransferase 21

Also known as: DHHC-21, DHHC21, DNZ1, HSPC097

NCBI Gene: 340481ENSG00000175893UniProt: Q8IVQ6OMIM: 614605

Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
11
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.74
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.74LOEUF
pLI 0.028
Z-score 2.26
OE 0.35 (0.18–0.74)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.32Z-score
OE missense 0.92 (0.80–1.07)
131 obs / 141.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.35 (0.18–0.74)
0≤0.351.4
Missense OE?0.92 (0.80–1.07)
0≤0.61.4
Synonymous OE?1.70
0≤1.21.6
LoF obs/exp: 5 / 14.2Missense obs/exp: 131 / 141.8Syn Z: -3.68

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZDHHC21 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients