ZDHHC16

Chr 10

zDHHC palmitoyltransferase 16

Also known as: APH2, DHHC-16

NCBI Gene: 84287ENSG00000171307UniProt: Q969W1

Enables palmitoyltransferase activity. Predicted to be involved in several processes, including eye development; protein palmitoylation; and telencephalon development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.68
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.68LOEUF
pLI 0.000
Z-score 2.82
OE 0.41 (0.26–0.68)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.77Z-score
OE missense 0.86 (0.76–0.96)
200 obs / 233.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.41 (0.26–0.68)
0≤0.351.4
Missense OE?0.86 (0.76–0.96)
0≤0.61.4
Synonymous OE?1.02
0≤1.21.6
LoF obs/exp: 11 / 26.8Missense obs/exp: 200 / 233.3Syn Z: -0.16

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZDHHC16 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients