ZDHHC11B

Chr 5

zDHHC palmitoyltransferase 11B (putative)

Also known as: DHHC-11B

NCBI Gene: 653082ENSG00000206077UniProt: P0C7U3

Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.64
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.64LOEUF
pLI 0.000
Z-score -0.43
OE 1.12 (0.77–1.64)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.81Z-score
OE missense 1.17 (1.04–1.30)
223 obs / 191.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.12 (0.77–1.64)
0≤0.351.4
Missense OE?1.17 (1.04–1.30)
0≤0.61.4
Synonymous OE?1.25
0≤1.21.6
LoF obs/exp: 18 / 16.1Missense obs/exp: 223 / 191.4Syn Z: -1.77

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZDHHC11B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients