ZDHHC11

Chr 5

zDHHC palmitoyltransferase 11

Also known as: ZNF399

NCBI Gene: 79844ENSG00000188818UniProt: Q9H8X9

Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
18
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.54
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.54LOEUF
pLI 0.000
Z-score -0.34
OE 1.08 (0.77–1.54)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.92Z-score
OE missense 1.17 (1.06–1.30)
259 obs / 220.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.08 (0.77–1.54)
0≤0.351.4
Missense OE?1.17 (1.06–1.30)
0≤0.61.4
Synonymous OE?1.28
0≤1.21.6
LoF obs/exp: 22 / 20.4Missense obs/exp: 259 / 220.6Syn Z: -2.22

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZDHHC11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients