ZDBF2
Chr 2zinc finger DBF-type containing 2
This gene encodes a protein containing DBF4-type zinc finger domains and is paternally expressed due to genomic imprinting. Mutations cause neurodevelopmental disorders with intellectual disability, and the gene shows high constraint against loss-of-function variants (LOEUF 0.46). The inheritance pattern involves paternal expression, meaning clinical manifestations depend on mutations inherited from the father.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZDBF2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools