ZC3H7A

Chr 16

zinc finger CCCH-type containing 7A

Also known as: HSPC055, ZC3H7, ZC3HDC7

NCBI Gene: 29066 ENSG00000122299 UniProt: Q8IWR0

The protein binds to specific microRNA hairpins and regulates microRNA biogenesis, recognizing the 3'-ATA(A/T)-5' motif in apical loops. Mutations cause autosomal dominant neurodevelopmental disorders with intellectual disability and developmental delay. This gene is highly constrained against loss-of-function variants (pLI=1.00, LOEUF=0.115), indicating intolerance to protein-truncating mutations.

ResearchSummary from RefSeq, UniProt

Enables miRNA binding activity. Involved in miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Located in cytosol. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.12

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

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