ZC3H12D

Chr 6

zinc finger CCCH-type containing 12D

Also known as: C6orf95, MCPIP4, TFL, dJ281H8.1, p34

NCBI Gene: 340152ENSG00000178199UniProt: A2A288OMIM: 611106

Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell growth. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
9
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.75
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.75LOEUF
pLI 0.156
Z-score 2.11
OE 0.29 (0.13–0.75)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.40Z-score
OE missense 0.76 (0.68–0.85)
203 obs / 267.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.29 (0.13–0.75)
0≤0.351.4
Missense OE?0.76 (0.68–0.85)
0≤0.61.4
Synonymous OE?0.68
0≤1.21.6
LoF obs/exp: 3 / 10.3Missense obs/exp: 203 / 267.6Syn Z: 2.75

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZC3H12D · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients