ZC3H12A
Chr 1zinc finger CCCH-type containing 12A
Also known as: MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1
ZC3H12A encodes an endoribonuclease that degrades inflammation-related mRNAs and regulates immune homeostasis, while also promoting glial differentiation of neuroprogenitor cells. Mutations cause autosomal recessive combined immunodeficiency with susceptibility to viral infections and warts. The gene is highly constrained against loss-of-function variants (LOEUF 0.51), indicating that complete loss of function is poorly tolerated.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZC3H12A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate Genes Encoding SOCS1 and Regnase-1, in Patients With Select Advanced Solid Tumors
RECRUITINGBCOR and ZC3H12 Genes Knock-out CD19-targeting CAR-T Cell Therapy in r/r B Cell Lymphoma
RECRUITINGExternal Resources
Links to major genomics databases and tools