ZC3H10

Chr 12

zinc finger CCCH-type containing 10

Also known as: ZC3HDC10

NCBI Gene: 84872ENSG00000135482UniProt: Q96K80

Enables miRNA binding activity. Involved in negative regulation of miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.61
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.61LOEUF
pLI 0.316
Z-score 2.53
OE 0.24 (0.11–0.61)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
2.28Z-score
OE missense 0.61 (0.54–0.69)
165 obs / 270.4 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.24 (0.11–0.61)
0≤0.351.4
Missense OE?0.61 (0.54–0.69)
0≤0.61.4
Synonymous OE?1.15
0≤1.21.6
LoF obs/exp: 3 / 12.7Missense obs/exp: 165 / 270.4Syn Z: -1.17

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZC3H10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients