ZBTB37

Chr 1

zinc finger and BTB domain containing 37

Also known as: D430004I08Rik, ZNF908

NCBI Gene: 84614 ENSG00000185278 UniProt: Q5TC79

The ZBTB37 protein is a transcriptional regulator that binds DNA and is predicted to negatively regulate RNA polymerase II transcription and immune system processes. This gene is highly constrained against loss-of-function variants (pLI 0.96, LOEUF 0.34), suggesting that mutations would likely cause severe developmental disorders, though specific associated diseases have not yet been established. The inheritance pattern for ZBTB37-related disorders has not been determined.

ResearchSummary from RefSeq, UniProt

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.34

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

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