ZBTB11
Chr 3ARzinc finger and BTB domain containing 11
Also known as: MRT69, ZNF-U69274, ZNF913
This gene encodes a DNA-binding transcription factor that regulates gene transcription in the nucleus. Biallelic mutations cause autosomal recessive intellectual developmental disorder 69. The gene is highly constrained against loss-of-function variants (pLI near 1, LOEUF 0.541), indicating intolerance to complete gene loss.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZBTB11 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools