ZBED4
Chr 22zinc finger BED-type containing 4
The ZBED4 protein is a transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription by RNA polymerase II. The gene is highly constrained against loss-of-function variants (LOEUF 0.405), suggesting that mutations would likely cause significant developmental or neurological effects. However, specific diseases associated with ZBED4 mutations and their inheritance patterns have not yet been clearly established in the clinical literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZBED4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools