YY1AP1

Chr 1

YY1 associated protein 1

Also known as: GRNG, HCCA1, HCCA2, YY1AP

NCBI Gene: 55249ENSG00000163374UniProt: Q9H869

Involved in cell differentiation; cell population proliferation; and regulation of cell cycle. Located in Ino80 complex; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtGrange syndrome
0
Active trials
5
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.31
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.31LOEUF
pLI 0.000
Z-score 0.23
OE 0.95 (0.71–1.31)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.18Z-score
OE missense 1.15 (1.07–1.24)
539 obs / 467.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.95 (0.71–1.31)
0≤0.351.4
Missense OE?1.15 (1.07–1.24)
0≤0.61.4
Synonymous OE?1.19
0≤1.21.6
LoF obs/exp: 28 / 29.3Missense obs/exp: 539 / 467.1Syn Z: -1.98

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

YY1AP1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients