YIPF7

Chr 4

Yip1 domain family member 7

Also known as: FinGER9, YIPFalpha1b, Yip1b

NCBI Gene: 285525ENSG00000177752UniProt: Q8N8F6OMIM: 619754

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within Golgi organization. Predicted to be located in cis-Golgi network; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.35
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.35LOEUF
pLI 0.000
Z-score 0.71
OE 0.78 (0.47–1.35)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.40Z-score
OE missense 1.10 (0.96–1.26)
141 obs / 128.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.78 (0.47–1.35)
0≤0.351.4
Missense OE?1.10 (0.96–1.26)
0≤0.61.4
Synonymous OE?1.27
0≤1.21.6
LoF obs/exp: 9 / 11.6Missense obs/exp: 141 / 128.2Syn Z: -1.44

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

YIPF7 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients