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XLID1
Chr XX-linkedIQ motif and Sec7 domain ArfGEF 2
Also known as: BRAG1, IQ-ArfGEF, MRX1, MRX18, MRX78, NEDXSB, XLID1
This protein functions as a guanine nucleotide exchange factor for ARF family GTPases and is a component of the postsynaptic density at excitatory synapses, where it regulates cytoskeletal and synaptic organization through activation of ARF1 and ARF6. Mutations cause X-linked intellectual developmental disorder 1, presenting as nonsyndromic cognitive disability. The condition follows X-linked inheritance.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/XLID1?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
XLID1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
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External Resources
Links to major genomics databases and tools