XCL2

Chr 1

X-C motif chemokine ligand 2

Also known as: SCM-1b, SCM1B, SCYC2

NCBI Gene: 6846 ENSG00000143185 UniProt: Q9UBD3 OMIM: 604828

The XCL2 protein functions as a chemokine with specific chemotactic activity for lymphocytes, binding to CCR chemokine receptors and mediating antimicrobial immune responses. This gene has low constraint against loss-of-function variants (pLI 0.009, LOEUF 1.79), and no established disease associations or inheritance patterns have been reported for XCL2 mutations in the current literature.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and chemokine-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be active in obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.78

LOEUF

Mechanism· predicted