WSB2

The protein functions as a substrate-recognition component of an E3 ubiquitin ligase complex that targets specific proteins for degradation through the ubiquitin-proteasome system. Mutations cause Luo-Agrawal neurodevelopmental syndrome, which follows an autosomal recessive inheritance pattern. The gene is highly constrained against loss-of-function variants, indicating that complete loss of protein function is likely incompatible with normal development.