WNT7B

Chr 22

Wnt family member 7B

NCBI Gene: 7477ENSG00000188064UniProt: P56706

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]

ResearchGenerating clinical summary…
1
Active trials
55
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.82
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.82LOEUF
pLI 0.001
Z-score 2.12
OE 0.45 (0.27–0.82)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.99Z-score
OE missense 0.65 (0.58–0.74)
171 obs / 261.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.45 (0.27–0.82)
0≤0.351.4
Missense OE?0.65 (0.58–0.74)
0≤0.61.4
Synonymous OE?1.24
0≤1.21.6
LoF obs/exp: 8 / 17.6Missense obs/exp: 171 / 261.7Syn Z: -2.02

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

WNT7B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients