WIPF2
Chr 17WAS/WASL interacting protein family member 2
Also known as: WICH, WIRE
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Clinical Summary— WIPF2
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Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.25) despite low pLI — interpret in context.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.54LOEUF
pLI 0.187
Z-score 3.06
OE 0.25 (0.13–0.54)
More LoF-intolerant than ~75% of genes
Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.16Z-score
OE missense 0.97 (0.88–1.08)
263 obs / 270.5 exp
Mild missense constraint
Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.25 (0.13–0.54)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.97 (0.88–1.08)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.1.01
0≤1.21.6
LoF obs/exp: 5 / 19.7Missense obs/exp: 263 / 270.5Syn Z: -0.10
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
WIPF2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype Relationships
1 OMIM entry
WAS/WASL-INTERACTING PROTEIN FAMILY, MEMBER 2; WIPF2
MIM #609692 · *
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
Clinical Efficacy and Transcriptomic Analysis of Congrong Shujing Granules () in Patients with Parkinson's Disease and Syndrome of Shen (Kidney) Essence Deficiency.
Chen SY et al.·Chin J Integr Med
2020Cohort
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Corrigendum: PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice.
Zhao Y et al.·Front Med (Lausanne)
2024Open Access
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice.
Zhao Y et al.·Front Med (Lausanne)
2024Open Access
The maize transcription factor CCT regulates drought tolerance by interacting with Fra a 1, E3 ligase WIPF2, and auxin response factor Aux/IAA8.
Zhang Z et al.·J Exp Bot
2024
Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis.
Tao Z et al.·Hum Exp Toxicol
2021
WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread.
Michard C et al.·Cell Microbiol
2019
Top 5 resultsSearch Europe PMC ↗
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
miR-7b-3p Exerts a Dual Role After Spinal Cord Injury, by Supporting Plasticity and Neuroprotection at Cortical Level
Ghibaudi M et al.·Front Mol Biosci
2021
Retraction notice: "Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis".
·Hum Exp Toxicol
2023
In silico identification and functional study of long non-coding RNA involved in acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus infection in white shrimp, Litopenaeus vannamei.
Olasard P et al.·Fish Shellfish Immunol
2024Functional
Comprehensive Analysis of Cell Population Dynamics and Related Core Genes During Vitiligo Development
Zhang J et al.·Front Genet
2021
Editorial: RNA metabolism and DNA stability in the central nervous system (CNS): from aging to neurodegenerative disease
Li T et al.·Front Mol Biosci
2024
Elaboration of the Homer1 recognition landscape reveals incomplete divergence of paralogous EVH1 domains
Singer A et al.·Protein Sci
2024
Respiratory Epithelial Cells: More Than Just a Physical Barrier to Fungal Infections
Barros BCSC et al.·J Fungi (Basel)
2022
Top 7 full-text resultsSearch PubTator3 ↗
External Resources
Links to major genomics databases and tools