WIF1

Chr 12

Wnt inhibitory factor 1

Also known as: WIF-1

NCBI Gene: 11197ENSG00000156076UniProt: Q9Y5W5OMIM: 605186

The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

OMIMResearchGenerating clinical summary…
1
Active trials
64
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.09
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.09LOEUF
pLI 0.000
Z-score 1.22
OE 0.73 (0.50–1.09)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.48Z-score
OE missense 0.91 (0.80–1.02)
185 obs / 204.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.73 (0.50–1.09)
0≤0.351.4
Missense OE?0.91 (0.80–1.02)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 17 / 23.4Missense obs/exp: 185 / 204.1Syn Z: 0.24

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

WIF1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients