WIF1
Chr 12Wnt inhibitory factor 1
Also known as: WIF-1
The protein inhibits WNT signaling by directly binding to WNT proteins and is involved in mesoderm segmentation during development. Mutations cause autosomal recessive omodysplasia, a skeletal dysplasia characterized by limb shortening, facial dysmorphism, and developmental abnormalities. The gene shows very low constraint against loss-of-function variants, consistent with the recessive inheritance pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
WIF1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
External Resources
Links to major genomics databases and tools