WDR73
Chr 15ARWD repeat domain 73
Also known as: GAMOS, GAMOS1, HSPC264
WDR73 encodes a cytoplasmic protein that assembles the RNA endonuclease module of the integrator complex by stabilizing the INTS9-INTS11 heterodimer before nuclear import. Biallelic mutations cause Galloway-Mowat syndrome 1, an autosomal recessive disorder affecting the central nervous system and kidneys. The gene shows extreme intolerance to loss-of-function variants (pLI near zero), indicating that heterozygous loss-of-function is likely benign.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
WDR73 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools