WDR5B-DT

Chr 3

WDR5B divergent transcript

I cannot provide a clinical summary for WDR5B-DT as no information about this gene's protein function, associated diseases, or inheritance pattern was provided in the data below the rules. Without supporting data about what the protein does and what conditions result from mutations, I cannot write an evidence-based clinical summary according to the specified guidelines.

Research

ResearchGenerating clinical summary…

Clinical Summary— WDR5B-DT

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ClinVar Variants

13 VUS of 27 total submissions

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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

27 submitted variants in ClinVar

ClinVar

Classification Summary

VUS13

Likely Benign1

Benign1

VUS

Likely Benign

Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	Missense + Inframe	Synonymous	Total
Pathogenic	0	0	0
Likely Pathogenic	0	0	0
VUS	13	0	13
Likely Benign	0	1	1
Benign	0	1	1
Total	13	2	15

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

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12 pathogenic / likely-pathogenic (of 13) ClinVar copy-number / structural variants overlap WDR5B-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →