VWA3A
Chr 16von Willebrand factor A domain containing 3A
Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
📖
Open GeneReview ↗GeneReview available — VWA3A
Authoritative clinical overview · Recommended first read
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.92LOEUF
pLI 0.000
Z-score 2.11
OE 0.72 (0.57–0.92)
Typical tolerance to LoF variation
Missense Constraint?
0.71Z-score
OE missense 0.92 (0.86–0.98)
581 obs / 631.5 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.72 (0.57–0.92)
0≤0.351.4
Missense OE?0.92 (0.86–0.98)
0≤0.61.4
Synonymous OE?0.84
0≤1.21.6
LoF obs/exp: 49 / 67.7Missense obs/exp: 581 / 631.5Syn Z: 2.00
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
VWA3A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
📖
Open GeneReview ↗GeneReview available — VWA3A
Authoritative clinical overview · NCBI Bookshelf · Recommended first read
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools