VSIG10L2

Chr 11

V-set and immunoglobulin domain containing 10 like 2

NCBI Gene: 338667 ENSG00000283703 UniProt: P0DP72

Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

GOF

Mechanism· predicted

Some data sources returned errors (2)

gnomad: Error: Gene not found

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in VSIG10L2?

gnomAD v4 · ~692k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 41

957 rare PASS variants

Rare truncating (LoF)

1 in 300

177 rare PASS variants

Rare synonymous (reference)

1 in 76

397 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for VSIG10L2. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~539k	1 in 55	1 in 320
South Asian	~40k	1 in 37	1 in 390
Remaining (unassigned)	~29k	1 in 31	1 in 130
African / African American	~21k	1 in 31	1 in 180
East Asian	~18k	1 in 45	1 in 240
Admixed American	~18k	1 in 27	1 in 150
European (Finnish)	~17k	1 in 170	1 in 450
Ashkenazi Jewish	~13k	1 in 120	1 in 730
Middle Eastern	~2,848	1 in 38	1 in 140

Each group is summed over the variants that are rare in that group. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 2 of 12 coding exons well covered in gnomAD exomes; exons 1, 10, 12 poorly covered; exons 2, 3, 4, 5, 7 and 2 more marginal. Genomes: all 12.? see exons ↓