VIRMA

Chr 8

vir like m6A methyltransferase associated

Also known as: KIAA1429, MSTP054, fSAP121

NCBI Gene: 25962 ENSG00000164944 UniProt: Q69YN4 OMIM: 616447

The VIRMA protein acts as a key regulator of RNA N6-methyladenosine (m6A) methylation by recruiting catalytic components to guide methylation at specific sites in mRNA 3'-UTRs, playing an essential role in mRNA splicing, processing, and polyadenylation. Mutations cause autosomal dominant neurodevelopmental disorder with developmental delay, intellectual disability, and behavioral abnormalities. This gene is highly constrained against loss-of-function variants, indicating that complete loss of function is likely incompatible with normal development.

OMIM ResearchSummary from RefSeq, UniProt

Enables RNA binding activity. Involved in mRNA processing. Located in RNA N6-methyladenosine methyltransferase complex; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.28

LOEUF· LoF intol.

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Mechanism