VIRMA
Chr 8vir like m6A methyltransferase associated
Also known as: KIAA1429, MSTP054, fSAP121
The VIRMA protein acts as a key regulator of RNA N6-methyladenosine (m6A) methylation by recruiting catalytic components to guide methylation at specific sites in mRNA 3'-UTRs, playing an essential role in mRNA splicing, processing, and polyadenylation. Mutations cause autosomal dominant neurodevelopmental disorder with developmental delay, intellectual disability, and behavioral abnormalities. This gene is highly constrained against loss-of-function variants, indicating that complete loss of function is likely incompatible with normal development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
VIRMA · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools