VEGFD
Chr XADvascular endothelial growth factor D
Also known as: FIGF, VEGF-D
The encoded protein is a secreted growth factor that stimulates angiogenesis, lymphangiogenesis, and endothelial cell growth by binding and activating VEGFR-2 and VEGFR-3 receptors. Mutations cause autosomal recessive primary lymphedema with predominantly lower limb involvement. This gene shows low constraint against loss-of-function variants, consistent with its recessive inheritance pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
VEGFD · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools