VCX3A

Chr X

variable charge X-linked 3A

Also known as: VCX-8r, VCX-A, VCX3, VCX8R, VCXA

NCBI Gene: 51481 ENSG00000169059 UniProt: Q9NNX9

VCX3A encodes a small, highly charged nuclear protein that may mediate processes in spermatogenesis, with exclusive expression in male germ cells. This gene belongs to a polymorphic gene family clustered on chromosome Xp22, where copy number varies between individuals. No established human diseases have been definitively associated with VCX3A mutations.

ResearchSummary from RefSeq, UniProt

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.87

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429