VCX2

Chr X

variable charge X-linked 2

Also known as: VCX-2r, VCX2R, VCXB

NCBI Gene: 51480ENSG00000177504UniProt: Q9H322

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes that are expressed exclusively in male germ cells. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This gene contains two copies of a 30 nt tandem repeat. Deletion of a nearby member of this family was implicated in cognitive disability. [provided by RefSeq, Feb 2015]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.94
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.94LOEUF
pLI 0.058
Z-score -1.82
OE 5.68 (0.41–1.94)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-4.99Z-score
OE missense 3.07 (1.89–2.00)
142 obs / 46.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?5.68 (0.41–1.94)
0≤0.351.4
Missense OE?3.07 (1.89–2.00)
0≤0.61.4
Synonymous OE?2.50
0≤1.21.6
LoF obs/exp: 1 / 0.2Missense obs/exp: 142 / 46.3Syn Z: -5.72

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

VCX2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients