UTS2R
Chr 17urotensin 2 receptor
Also known as: GPR14, UR-2-R, UTR, UTR2
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Clinical Summary— UTS2R
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.93LOEUF
pLI 0.000
Z-score -0.84
OE 1.44 (0.73–1.93)
Highly tolerant — LoF variants common in population
Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.70Z-score
OE missense 0.87 (0.78–0.98)
205 obs / 235.1 exp
Mild missense constraint
Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.1.44 (0.73–1.93)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.87 (0.78–0.98)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.95
0≤1.21.6
LoF obs/exp: 6 / 4.2Missense obs/exp: 205 / 235.1Syn Z: 0.42
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
UTS2R · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype Relationships
1 OMIM entry
G PROTEIN-COUPLED RECEPTOR 14; GPR14
MIM #600896 · *
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
Ogawa A et al.·Commun Biol
2023
Using exome sequencing to identify the cause of myocardial hypertrophy in a Chinese family.
Pu T et al.·Mol Med Rep
2015
Severe myocardium suppression in two congenital heart disease patients after remdesivir use - a case report.
Lin YF et al.·BMC Pediatr
2025Case report
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Novel Mutations in UTS2R are Associated with Adolescent Idiopathic Scoliosis in the Chinese Population.
Dai Z et al.·Spine (Phila Pa 1976)
2021
UTS2R gene polymorphisms are associated with fatty acid composition in Japanese beef cattle.
Sasazaki S et al.·Anim Sci J
2014
Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus.
Jiang Z et al.·Int J Biol Sci
2008Open Access
Top 5 resultsSearch Europe PMC ↗
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Impact of Classic Adrenal Secretagogues on mRNA Levels of Urotensin II and Its Receptor in Adrenal Gland of Rats
Jopek K et al.·Int J Mol Sci
2023
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration
Gao B et al.·Adv Sci (Weinh)
2022
Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis
Yang Y et al.·Front Genet
2022
Antagonizing urotensin receptor is a novel therapeutic strategy for glucocorticoid-induced skeletal muscle atrophy
Yin L et al.·Clin Transl Med
2022
Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma
Le Joncour V et al.·Front Cell Dev Biol
2021
Top 7 full-text resultsSearch PubTator3 ↗
External Resources
Links to major genomics databases and tools