USP9X

The protein is a ubiquitin-specific protease that removes ubiquitin from target proteins in the cytoplasm. Loss-of-function mutations cause X-linked intellectual developmental disorder 99, which can present as either a syndromic female-restricted form or a non-syndromic form affecting both males and females. The inheritance pattern can be either X-linked recessive or X-linked dominant depending on the specific mutation and clinical presentation.